He is an HIV and TB immunologist focused on studying the immune response to these pathogens in affected tissues, and how this relates to what can be observed from the blood. The research goal is to improve understanding of the immunopathology of TB and HIV, using this information to aid in developing novel therapeutic approaches and diagnostic biomarkers.
His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M. His work has a strong translational component, asking if both classically and non-classically restricted T cells are associated with infection with M. The translational significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB.
Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus.
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